Olympic Hall 1

Olympic Hall 2

08:30-09:00: Welcome – Opening ceremony

Theodoros Sklaviadis, Congress Chairman

Jean-Philippe Deslys, Neuroprion Coordinator

9:00-9:30 Plenary talk

Chair:Theodoros Sklaviadis, Jean-Philippe Deslys

Charles Weissmann, Jiali Li, Shawn Browning, Sukhvir P. Mahal, Anja Oelschlegel

Department of Infectology, Scripps Florida, USA

Heterogeneity of prion populations

9:40-11:00: 1. Protein Misfolding

Chair: Claudio Soto, Umberto Agrimi

9:40-10:55: 2. Diagnostics, Therapeutics & Decontamination

Chair:Detlev Riesner, Hans Kretzschmar

9:40-10:00

Tamar Canello¹, Silvia Lisa², Jackob Moskovitz³, Maria Gasset²,Ruth Gabizon¹

¹Hadassah University Hospital, Israel; ²Instituto de Química-Física "ROCASOLANO", Spain; ³University of Kansas, USA

Oxidation of Met residues on PrP: An early event in prion formation and disease manifestation

09:40-10:00

Inga Zerr

National TSE Reference Center, Göttingen, Germany

Clinical diagnosis of CJD: are there predictors of treatment response?

10:00-10:20

Alexander Peden¹, Graham Fairfoul¹, Suzanne Lowrie¹, Linda McCardle¹, Mark Head¹, Seth Love², Hester Ward¹, Simon Cousens³, David Keeling⁴, Carolyn Millar⁵, FGH Hill⁶, James Ironside¹

¹University of Edinburgh, UK; ²Frenchay Hospital, Bristol, UK; ³London School of Hygiene and Tropical Medicine, UK; ⁴Churchill Hospital, Oxford, UK; ⁵Imperial College London, UK; ⁶Birmingham Children´s Hospital, Birmingham, UK

vCJD infection in an asymptomatic UK haemophilic patient

10:00-10:20

Agnieszka Salwierz¹, Eva Birkmann^1,2, Detlev Riesner¹

Heinrich-Heine Universitaet Duesseldorf, Germany; ²Forschungszentrum Juelich

Studies on the interaction of membrane-bound PrP^C with PrP^Sc

10:20-10:40

María Gasset

IQFR-CSIC, Spain

Structural intolerance of PrPα-fold for Helix-3 methionine oxidation: the link of theory and experiment

10:20-10:40

Detlev Riesner

Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Germany

Detection of prion particles in body fluids of humans and animals

10:40-11:00

Will Guest¹, Li Li¹, Olivier Julien², Subhrangsu Chatterjee², Brian Sykes², Wenquan Zou³, Steven Plotkin¹, Neil Cashman¹

¹University of British Columbia, Canada, ²University of Alberta, Canada, ³Case Western Reserve University, USA

Partial unfolding of the prion protein: early steps on the path to misfolding

10:40-10:55

Linda A. Terry, Laurence Howells, Jeremy Hawthorn, Sally Everest, Sarah Jo Moore, Jane C. Edwards

Veterinary Laboratories Agency, UK

Detection of prions in blood leucocytes

11:00-11:30 Coffee break

11:30-12:50: 1. Protein Misfolding

Chair:Jesús Requena, Ruth Gabizon

11:30-12:45: 2. Diagnostics, Therapeutics & Decontamination

Chair:Maurizio Pocchiari, Inga Zerr

11:30-11:50

Federico Benetti¹, Heinz Amenitsch^2,3, Matthijn Vos⁴, Adriana Ramos⁵, Peter Peters⁶, Giuseppe Legname^1,3, Jesús Requena⁵

¹Scuola Internazionale Superiore di Studi Avanzati, Italy; ²Austrian Academy of Sciences, Austria; ³ELETTRA Laboratory, Sincrotrone Trieste S.C.p.A, Italy; ⁴The FEI Company, Netherlands; ⁵University of Santiago de Compostela, Spain; ⁶Netherlands Cancer Institute, Netherlands

SAXS Analysis of PrP^Sc and oligomeric recombinant mouse PrP(89-230)

11:30-11:45

Chrysanthi Berberidou, Konstantinos Xanthopoulos, Eleni Paulidou, Eleni Polyzoidou, Thanasis Lourbopoulos, Ioannis Poulios, Theodoros Sklaviadis

Aristotle University of Thessaloniki, Greece

Decontamination of prion infected metal surfaces employing the photo-Fenton reagent

11:45-12:00

Silvio Notari¹, Liuting Qing¹, Ayuna Dagdanova¹, Sergei Ilchenko¹, Mark E. Obrenovich¹, Wen-Quan Zou¹, Maurizio Pocchiari², Pierluigi Gambetti¹, Qingzhong Kong¹, Shu G. Chen¹

¹Case Western Reserve University, USA; ²Istituto Superiore di Sanità, Italy

Human urine and PrP

11:50-12:10

Nathalie Daude¹, Vivian Ng², Joel Watts³, Sacha Genovesi¹, Serene Wohlgemuth¹, Jean-Paul Glaves¹, Howard Young¹, Gerold Schmitt-Ulms², Joanne Mclaurin², Paul E. Fraser², David Westaway ¹

¹University of Alberta, Canada; ²University of Toronto, Canada; ³University of San Francisco, USA

The PrP-like Shadoo protein converts to amyloid at neutral pH

12:00-12:15

Kazuo Kuwata, Tsutomu Kimura, Yuji O. Kamatari, Junji Hosokawa-Muto, Keiichi Yamaguchi, Takeshi Ishikawa, Takakazu Ishikura, Norifumi Yamamoto, Yumiko Okuda

Center for Emerging Infectious Diseases, Gifu University, Japan

Rational design of anti-prion compounds targeting the PrP* characteristic sites

12:10-12:30

Human Rezaei¹, Stephanie Prigent¹, Nesrine Chakroun², Celine Chapuis¹, Cecile Dreiss², Franca Fraternali²

¹INRA, France; ²King's College, UK

Conformational dynamic of the PrP minimal domain involved in the oligomerization process

12:15-12:30

Andreas Mueller-Schiffmann¹, Max Michel¹, Benjamin Petsch², Lothar Stitz², Carsten Korth¹

¹University of Duesseldorf, Germany; ²Friedrich Löffler Institute, Tuebingen, Germany

A PrP^Sc specific peptide derived from an antibody against PrP^C/^Sc

12:30-12:50

Fabiana Caetano^1,4, Iaci Soares¹, Grace Pereira¹, Marilene Lopes², Nicolle Queiroz², Stephen Ferguson³, Vania Prado^1,3, Vilma Martins²; Marco Prado^1,3

¹Universidade Federal de Minas Gerais, Brazil; ²Ludwig Institute for Cancer Research, Sao Paulo, Brazil; ³University of Western Ontario, Canada

Nuclear trafficking of STI1, a prion binding protein, induced by SUMOylation

12:30-12:45

Adriana Gielbert, Mark Arnold, Peter Griffiths, John Spiropoulos, Maurice Sauer

Veterinary Laboratories Agency, UK

N-Terminal amino acid profiling (N-TAAP) shows unexpected and distinct differences between PrPres from atypical and classical scrapie

13:00-14:20: Lunch (Meliton Hotel) / Poster Session (Olympic Hall 3)

14:30-15:00 Plenary talk

Chair:Robert Will, Nikolaos Taskos

Thomas Wisniewski

New York University School of Medicine, USA

Therapeutic Approaches for Alzheimer´s and Prion Diseases

15:10-16:30: 3. Other neurodegenerative proteinopathies

Chair:Robert Will, Nikolaos Taskos

15:10-15:30

Konrad Beyreuther

Network Aging Research and ZMBH; University Heidelberg, Germany

Novel therapeutic approaches in Alzheimer´s disease

15:30-15:50

Fabrizio Tagliavini¹, Marcella Catania¹, Michela Morbin¹, Marco Gobbi², Laura Colombo², Antonio Bastone², Laura Cantù³, Efrat Levy⁴, Maria Salmona², Giuseppe Di Fede¹

¹¨Carlo Besta¨ Neurological Institute, Milano, I; ^2¨Mario Negri¨ Institute for Pharmacological Research, Milano, I; ³University of Milan, Milano, I; ^4¨Nathan S. Kline¨ Institute, Orangeburg, NY, USA

Good protein, bad protein: A new Aβ variant can be both

15:50-16:10

Magdalini Polymenidou¹, Clotilde Lagier-Tourenne¹, Tiffany Liang², Gene Yeo² Don W. Cleveland^1,2

¹Ludwig Institute for Cancer Research, University of California in San Diego, USA; ²Cellular and Molecular Medicine, University of California in San Diego, USA

Role of RNA processing in the pathogenesis of amyotrophic lateral sclerosis

16:10-16:30

Hermann M. Schätzl

Institute of Virology, Technische Universität München, Munich, Germany

Autophagy and its role in neurodegenerative diseases

16:30-17:00: Coffee break

17:00-18:20:4. Transmission & Pathogenesis

Chair: Jean Manson, Eleni Kaldrymidou

17:00-18:20: 5. Basic Mechanisms of Neurodegeneration & Pathology

Chair: Jan Langeveld, Edward Hoover

17:00-17:20

Jean Manson

University of Edinburgh, UK

TSE strains and their transmission within and between animals

17:00-17:20

Herbert Budka

Institute of Neurology, Medical University Vienna, Austria

Molecular neuropathology of TSEs

17:20-17:40

Olivier Andreoletti¹, Nathalie Morel², Caroline Lacroux¹, Stéphanie Simon², Séverine Lugan¹, Jean-Louis Weisbecker³, Pierrette Costes¹, Fabien Corbiere¹, Jacques Grassi¹, François Schelcher¹

¹UMR INRA ENVT 1225 Interactions Hôte agent pathogène, France; ²CEA, Service de Pharmacologie et d'Immunoanalyse, IBiTec-S, DSV, CEA/Saclay, France; ³INRA Domaine de Langlade, France

TSE genetic resistance and allelic interference in sheep

17:20-17:40

Martin Jeffrey¹, Bruce Chesebro², Brent Race², Gillian McGovern¹

¹Veterinary Laboratories Agency, UK; ²Rocky Mountain Laboratories, USA

Patterns of abnormal PrP drainage and amyloid formation in scrapie infected mice expressing GPI-anchorless PrP

17:40-18:00

Pedro Fernandez-Funez¹, Sergio Casas-Tinto¹, Yan Zhang¹, Wen-Quan Zou², Diego Rincon-Limas¹

¹University of Texas Medical Branch, USA, ²Case Western Reserve University, USA

Sequence-dependent pathobiology of prion proteins: lessons from rabbits, mice and hamsters

17:40-18:00

Edgar Holznagel¹, Walter Schulz-Schaeffer², Barbara Yutzy¹, Gerhard Hunsmann³, Johannes Loewer¹

¹Paul-Ehrlich-Institut, Federal Institute for Sera and Vaccines, Germany; ²Department of Neuropathology, Georg-August University, Göttingen, Germany, ³Department of Virology and Immunology, German Primate Centre, Göttingen, Germany

Spread of BSE prions in cynomolgus monkeys (Macaca fascicularis) after oral transmission

18:00-18:20

Sabrina Cronier¹, Julie Carimalo², Brigitte Schaeffer³, Marie-Christine Miquel⁴, Hubert Laude¹, Jean-Michel Peyrin⁵

¹INRA U892 VIM, France; ²Reference Center for TSE Surveillance UMG, Germany; ³INRA MIA, France; ⁴CNRS UMR 5241 UPS, France; ⁵CNRS UMR 7102 UPMC, France

Endogenous PrP conversion is required for prion-induced neuritic alterations and neuronal death

18:00-18:20

Anne Buschmann¹, Ute Ziegler¹, Leila McIntyre², Markus Keller¹, Ron Rogers³, Bob Hills³, Martin H. Groschup¹

¹Friedrich-Loeffler-Institut, INEID, Germany; ²Faculty of Veterinary Medicine, University of Calgary, Canada; ³Health Canada, Ottawa, Canada

PrP^Sc distribution pattern in cattle experimentally challenged with H-type and L-type atypical BSE

18:20-18:50

Talks by two young researchers from the Neuroprion network, selected after training in scientific communication

Chair:Jean Philippe Deslys

18:50-20:30: Poster Party (Olympic Hall 3)

Olympic Hall 1

Olympic Hall 2

Plenary talk

Chair: Juan Maria Torres, Stavros Balogiannis

9:00-9:30

Laura Manuelidis

Yale University Medical School, USA

What agent strains tell us

10:00-11:00: 5. Basic mechanisms of neurodegeneration & Pathology

Chair: Herbert Budka, Maria Gasset

9:30-11:00: 4. Transmission & Pathogenesis

Chair: Juan Maria Torres, Stavros Balogiannis

10:00-10:20

Benoit Schneider¹, Damien Loubet¹, Elodie Pradines¹, Yannick Bailly², Jean-Michel Peyrin³, Hubert Laude³, Catherine Vidal¹, Jean-Marie Launay¹, Sophie Mouillet – Richard¹, Odile Kellermann¹

¹INSERM U747 - Université Paris Descartes, France; ²CNRS UPR 3212, France; ³INRA, France

Prion replication sensitized neurons to pro-inflammatory cytokines

9:30-10:00

Edward A. Hoover¹, Nicholas J. Haley¹, Candace K. Mathiason¹, Nathanial D. Denkers¹, Davis M. Seelig¹, and Glenn C. Telling²

¹Colorado State University, USA; ²University of Kentucky, Lexington, USA

Recent results on the transmission, detection, and pathogenesis of chronic wasting disease

10:00-10:20

Sandra McCutcheon¹, Anthony Richard Alejo Blanco¹, Christopher de Wolf¹, Boon Chin Tan¹, Nora Hunter¹, Valerie Hornsey², Christopher Prowse², Marc Turner², Martin H Groschup³, Dietmar Becher⁴, Fiona Houston⁵, Jean C Manson¹

¹The Roslin Institute and R (D) SVS, University of Edinburgh, UK; ²Scottish National Blood Transfusion Service, UK; ³FLI-Federal Research Institute for Animal Health, Germany; ⁴Micromun, Germany; ⁵University of Glasgow, UK

All separated components, prepared from BSE-infected sheep blood, are infectious upon transfusion

10:20-10:40

Anna Majer¹, Sarah Medina², Reuben Saba¹, Debra Parchaliuk², Kathy Frost², Catherine Robertson², Stephanie Booth²

¹University of Manitoba, Canada; ²Public Health Agency of Canada, Canada

The investigation of dysregulated microRNAs in prion – induced neurodegeneration

10:40-11:00

Mohammed Moudjou, Michel Dron, Jérôme Chapuis, Julie Bernard, Muhammad K. F. Salamat, Sabrina Cronier, Christelle Langevin, Hubert Laude

INRA, France

Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent

10:20-10:40

Lorenzo Gonzalez¹, Silvia Siso¹, Stuart Martin¹, Steve A.C. Hawkins¹, Wilfred Goldmann², Timm Konold¹, James Hope¹, Martin Jeffrey¹

¹Veterinary Laboratories Agency, UK; ²Roslin Institute, UK

Pathogenesis of scrapie in goats: modulation by host PRNP genotype and effect of coexistent conditions

10:40-11:00

Xiangmei Zhou¹, Haiyun Zhou¹, Mohammed Kouadir¹, Zhongqiu Zhang², Lifeng Yang¹, Deming Zhao¹

¹China Agricultural University; ²China Animal Disease Control Center, China

Induction of macrophage migration by neurotoxic prion protein fragment

11:00-11:30 Coffee break

11:30-12:50: 6. Functions & Cell biology of PrP

Chair:Olivier Andreoletti , Magda Tsolaki

11:30-13:00: 7. Genetics

Chair:Fabrizio Tagliavini, Pierluigi Gambetti

11:30-11:50

Cathryn Haigh¹, Amelia McGlade¹, Simon Drew¹, Martin Boland¹, Colin Masters², Kevin Barnham¹, Victoria Lawson¹, Steven Collins¹

¹The University of Melbourne, Australia; ²The Mental Health Research Institute, Australia

Synergy of polybasic structure and copper co-ordination in the PrP23-89-mediated stress protection response

11:30-12:00

John Collinge

MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London

Understanding genetic susceptibility to human prion diseases

12:00-12:30

David Westaway^1,2,3, Nathalie Daude¹, Sacha Genovesi1, Inyoul Lee⁴, Jing Yang¹, Rebecca Young⁵, and George A. Carlson⁵

¹Centre for Prions and Protein Folding Diseases, University of Alberta;  ²Division of Neurology, Faculty of Medicine, University of Alberta; ³Department of Biochemistry, University of Alberta; ⁴Institute for Systems Biology, University of Washington; ⁵McLaughlin Research Institute, Great Falls Montana

Properties of the Shadoo Protein in Health and Prion Disease

11:50-12:10

Gerold Schmitt-Ulms¹, Joel Watts², Sepehr Ehsani¹, Hairu Huo¹, Yu Bai³, Holger Wille², David Westaway⁴

¹University of Toronto, Canada; ²University of California San Francisco, USA; ³Peking University, China; ⁴University of Alberta, Canada

Family reunion - encounter of molecular cousins uncovers founder and ancient function of prion gene family

12:10-12:30

Michel Dron¹, Françoise Dandoy-Dron², Muhammad Khalid Farooq Salamat¹, Hubert Laude¹

¹INRA, France; ²CNRS, France

Proteasome inhibitors induce accumulation of a detergent-insoluble PrP26K and formation of PrP^Sc aggresomes in prion–infected CAD cells

12:30-12:45

Simon Mead, Jerome Whitfield, Mark Poulter, Paresh Shah, James Uphill, Tracy Campbell, Huda Al-Dujaily, Holger Hummerich, Jon Beck, Charles A Mein, Claudio Verzilli, John Whittaker, Michael Alpers, John Collinge

Medical Research Council, UK

A novel protective prion protein variant co-localises with kuru exposure

12:30-12:50

Rafael Mariante, Alberto Nóbrega, Maria Bellio, Rafael Liden

Federal University of Rio de Janeiro

Neuroimmunoendocrine regulation of the prion protein in neutrophils

12:45-13:00

Jon Beck¹, Diego Kaski¹, Catherine Pennington², Mark Poulter¹, James Uphill¹, Matthew Bishop², Jackie Linehan¹, Catherine O'Malley¹, Sebastian Brandner¹, Richard Knight³, John Collinge¹, Simon Mead¹

¹MRC Prion Unit at the National Prion Clinic, UK; ²National Hospital for Neurology and Neurosurgery, UK; ³National CJD Surveillance Unit, UK

Inherited prion disease with 4-octapeptide repeat insertion – disease requires the interaction of multiple genetic risk factors

13:00-14:20 Lunch (Meliton Hotel) / Poster session (Olympic Hall 3)

14:30-16:35:8. IPFA/FABS/LFB: Blood safety and prions

Chair:Paul Brown

14:30-14:55

Robert G. Will

National CJD Surveillance Unit, Edinburgh, UK

Variant CJD and plasma products

14:55-15:20

Marc Turner

Scottish National Blood Transfusion Service and Department of Haematology, Royal Infirmary, Edinburgh, UK

Blood safety: from screening tests to prion removal

15:20-15:45

Byron Caughey

Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840

Structural analyses and detection of prion proteins: from rapid diagnosis to therapeutic development

15:45-16:10

Claudio Soto,Marcelo Barria, Baian Chen, ense Gonzalez-Romero, Abhisek Mukherjee, Rodrigo Morales

University of Texas Medical School at Houston, USA

Quantification of PrPSc in different blood fractions, brain and peripheral tissues at distinct stages of prion disease

16:10-16:35

Conrad G. Brunk

Department of Philosophy, University of Victoria, Canada

Ethical implications of prion blood screening tests

16:35-17:00 Coffee break

17:00-18:20: 9. Epidemiology & Risk assessment

Chair:Michael Dawson, Nikolaos Papaioannou

17:00-18:35: 10. Natural & experimental strains

Chair:Hubert Laude, Penelope Papasavva Stylianou

17:00-17:20

Alexandre Fediaevsky¹, Cristiana Maurella², Maria Nöremark³, Francesco Ingravalle², Stefania Thorgeirsdottir⁴, Leonor Orge⁵, Renaud Poizat⁶, Maria Hautaniemi⁷, Barry Liam⁸, Didier Calavas⁹, Giuseppe Ru², Petter Hopp

¹AFSSA-Lyon; INRA Clermont-Theix, France; ²Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d´Aosta, Italy; ³National Veterinary Institute, Sweden; ⁴University of Iceland, Iceland; ⁵Laboratório Nacional de Investigação Veterinária, Portugal; ⁶AFSCA, Portugal; ⁷Finnish Food Safety Authority, Finland; ⁸Department of Agriculture, Fisheries and Food, Ireland; ⁹AFSSA-Lyon, France, ¹⁰National Veterinary Institute, Norway

No evidence of contagiousness of atypical scrapie: results from a 12-country European study

17:00-17:20

Vincent Béringue, Hubert Laude.

INRA, UR 892, Virologie Immunologie Moléculaires, France

Transmission of atypical bovine prions to mice transgenic for human prion protein

17:20-17:35

David Colby, Giuseppe Legname, Holger Wille, Ilia Baskakov, Stephen DeArmond, Stanley Prusiner

University of California, San Francisco, USA

Generation of diverse synthetic prion strains capable of infecting mice that express full-length prion protein

17:20-17:40

Robert Somerville, Karen Fernie, Allister Smith

University of Edinburgh, UK

Survival and limited spread of TSE infectivity after burial for one year

17:35-17:50

Umberto Agrimi¹, Michele Di Bari¹, Claudia D'Agostino¹, Elena Esposito¹, Maria Mazza², Simone Barocci³, Geraldina Riccardi¹, Shimon Simson¹, Paolo Frassanito¹, Barbara Iulini², Pier Luigi Acutis², Cristina Casalone², Hubert Laude⁴, Sylvie Benestad⁵, Gabriele Vaccari¹, Romolo Nonno¹

¹Istituto Superiore di Sanità, Italy; ²Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Italy; ³Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, Italy, ⁴INRA, France; ⁵National Veterinary Institute, Norway

Separation of prion strains from a mixture by discriminatory bioassay. The example of a natural case of mixed infection of classical scrapie and Nor98

17:40-18:00

Hong Yang, Richard Forshee, Mark Walderhaug, Steven Anderson

US Food and Drug Administration, USA

Updated risk assessment of variant Creutzfeldt-Jakob disease (vCJD) risks for recipients of plasma-derived blood clotting products in the US

18:00-18:20

Sylvie Benestad¹, Torfinn Moldal¹, Torkjel Bruheim², Petter Hopp¹, Bjorn Bratberg¹

¹National Veterinary Institute, Oslo, Norway, ²National Veterinary Institute, Trondheim, Norway

Is Nor98 scrapie contagious? Results from Norwegian flock studies

17:50-18:05

Sílvia Sisó¹, Francesca Chianini², Scott Hamilton², Mark Dagleish², Philip Steele², Jeanie Finlayson², Stuart Martin¹, Martin Jeffrey¹, Lorenzo González¹

¹Veterinary Laboratories Agency- Lasswade, UK; ²Moredun Research Institute, UK

Significance of murine scrapie strains: ME7 changes phenotype when inoculated in sheep and then back into mice

18:05-18:20

Pierluigi Gambetti

Case Western Reserve University, USA

A novel human prion disease affecting subjects with the three prion protein codon 129 genotypes: Could it be the sporadic form of Gerstmann-Sträussler

18:20-18:35

Romolo Nonno¹, Michele Di Bari¹, Laura Pirisinu¹, Stefano Marcon¹, Claudia D´Agostino¹, Elena Esposito¹, Paola Fazzi¹, Shimon Simson¹, Paolo Frassanito¹, Cristina Casalone³, Franco Cardone², Maurizio Pocchiari², Gabriele Vaccari¹, Umberto Agrimi¹

¹Dept. SPVSA, Istituto Superiore di Sanità, Italy; ²Dept. BCN, Istituto Superiore di Sanità, Italy; ³Istituto Zooprofilattico del Piemonte, Liguria e Valle D´Aosta, Italy

Biological typing of sporadic Creutzfeldt-Jakob disease isolates and comparison with animal prion isolates

18:35-19:05: Plenary talk

Chair:Paul Brown

Lev G. Goldfarb

Bethesda, Maryland, U.S.A.

In memory of Dr Daniel Carleton Gajdusek (1923 - 2008)

Announcement of poster prize winners

Announcement of the grants awarded for the 2009 call by the Alliance Biosecure Foundation

19:10-19:40: Anne-Charlotte Panissié

A journey through Greek mythology and history, the figure of Homer

20:30 Gala Dinner (Meliton Hotel)

Olympic Hall 2

8:15-9:30: 11. Hot topics

Chair: Hermann Schätzl, Vasilios Kokkas

8:15-8:30

Gültekin Tamgüney^1,2, Michael W. Miller³, Lisa L. Wolfe³, Tracey M. Sirochman³, David V. Glidden⁴, Christina Palmer ¹, Azucena Lemus⁵, Stephen J. DeArmond⁵, Stanley B. Prusiner^1,2

¹Institute for Neurodegenerative Diseases, University of California, San Francisco, USA; ²Department of Neurology, University of California, San Francisco, USA; ³Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, USA; ⁴Department of Epidemiology and Biostatistics, University of California, San Francisco, USA; ⁵Department of Pathology, University of California, San Francisco, USA

Prions in feces of asymptomatic deer

8:30-8:45

Emmanuel Comoy¹, Juergen Richt², Valárie Durand¹, Sophie Freire¹, Evelyne Correia¹, Amir Hamir², Marie-Madeleine Ruchoux¹, Paul Brown¹, Jean-Philippe Deslys¹

¹Atomic Energy Commission, France; ²National Animal Disease Center, USA

Transmission of bovine-passaged TME prion strain to macaque

8:45-9:00

Silvia Suardi¹, Chiara Vimercati¹, Fabio Moda¹, Ruggerone Margherita¹, Ilaria Campagnani¹, Guerino Lombardi², Daniela Gelmetti², Martin H Groschup³, Anne Buschmann³, Cristina Casalone⁴, Maria Caramelli⁴, Salvatore Monaco⁵, Gianluigi Zanusso⁵, Fabrizio Tagliavini¹

¹Carlo Besta" Neurological Institute,Italy; ²IZS Brescia, Italy; ³3FLI Insel Riems, D, Germany; ⁴CEA-IZS Torino, Italy; ⁵University of Verona, Italy

Infectivity in skeletal muscle of BASE-infected cattle

9:00-9:15

Edward Málaga-Trillo, Gonzalo P. Solis, Claudia A.O. Stuermer, Yvonne Schrock, Emily Sempou, Corinna Geiss

Department of Biology, University of Konstanz, Germany

The use of zebrafish in prion biology: lessons and perspectives

9:15-9:30

Steve Simoneau, Jean-Guy Fournier

Small critical RNAs in the scrapie agent

9:30-10:20 Round table :Sustaining prion research: from past to future

Chair: Christian Patermann

Jim Hope: Situation in UK

Neil Cashman: Developing in Canada a full spectrum of research activities on prion

Charles Weissmann: Prion research from Europe to US

Christian Patermann: Synthesis: strengthening a durable integration of prion research

10:20-10:35 Family session

CJD International Support Alliance, Building a Global Prion Disease Support Community

Florence Kranitz, President of the CJD Foundation

Susane Solvyns, CJD Support Group Network, Australia; Co-Chair of the CJD International Support Alliance

10:35-11:45: Poster prize winners presentations

Chair: Jean Philippe Deslys, David Westaway

11:45-12:00 Closing ceremony / Next meeting announcement